Partially-coated TFBGs for biosensing

Tianbo Zhu; Médéric Loyez; Karima Chah; Christophe Caucheteur

doi:10.1117/12.2625408

17 May 2022 Partially-coated TFBGs for biosensing

Tianbo Zhu, Médéric Loyez, Karima Chah, Christophe Caucheteur

Proceedings Volume 12139, Optical Sensing and Detection VII; 121391P (2022) https://doi.org/10.1117/12.2625408
Event: SPIE Photonics Europe, 2022, Strasbourg, France

Conference Poster

Abstract

This study investigates a fiber-optic biosensor based on a tilted fiber Bragg grating (TFBG) partially-coated with a thin gold film on its axis and around its cross-section. The effects induced in the TFBG transmitted amplitude spectrum were analyzed for different input light directions for surrounding refractive index (SRI) changes in the range 1.3356 – 1.3370. Partially-coated gratings present the potential ability to sense both volume and surface refractive index changes, which is interesting in biosensing to enhance the signal-to-noise ratio. The gold film was bio-functionalized by human epidermal growth factor receptor (HER2) aptamers using thiol chemistry. The detection of HER2 proteins (a relevant cancer biomarker) at 10-9 g/mL, 10-8 g/mL and 10-6 g/mL demonstrated the advantage to identify environmental perturbations through the bare area of the TFBG. The non-specific drifts that could exist in samples are eliminated and a wavelength shift only related to the surface modification is obtained.

Conference Presentation

Citation Download Citation

Tianbo Zhu, Médéric Loyez, Karima Chah, and Christophe Caucheteur "Partially-coated TFBGs for biosensing", Proc. SPIE 12139, Optical Sensing and Detection VII, 121391P (17 May 2022); https://doi.org/10.1117/12.2625408

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available