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Optical and optoacoustic imaging have now progressed beyond critical boundaries in contrast and penetration depth of optical methods, enabling the use of light for a variety of research and clinical applications. The talk discusses advances in multi-spectral optoacoustic tomography (MSOT) and optoacoustic mesoscopy and microscopy that impart unprecedented optical imaging performance in visualizing anatomical, physiological, and molecular biomarkers invivo. In particular, we illuminate how MSOT visualizes biomarkers that relate to inflammatory and metabolic processes in a safe and portable manner, and the role of these biomarkers in addressing unmet clinical needs. Applications including imaging of breast cancer, brown fat activation, or inflammatory conditions of the skin and bowels are showcased as examples of the clinical potential. We discuss how MSOT is appropriate for disseminated, frequent and longitudinal imaging, and how applications in hybrid mode, together with ultrasonography, offer novel potential for advancing diagnostics and theranostics. We further highlight recent progress in the label-free imaging of molecules using Mid-IR Optoacoustic Microscopy (MiROM), a novel modality that pushes the limits of visualization in optical microscopy. Finally, we discuss progress in fluorescence molecular imaging (FMI), which not only has the potential to improve surgical procedures, but now also contributes to early diagnostics, such as the detection of cancerous lesions in patients with Barrett’s esophagus. Please verify that (1) all pages are present, (2) all figures are correct, (3) all fonts and special characters are correct, and (4) all text and figures fit within the red margin lines shown on this review document. Complete formatting information is available at http://SPIE.org/manuscripts Return to the Manage Active Submissions page at http://spie.org/submissions/tasks.aspx and approve or disapprove this submission. Your manuscript will not be published without this approval. Please contact authorhelp@spie.org with any questions or concerns. 12146
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