Characterization of age-related follicle changes in mice ovaries using optical coherence tomography

Marcello Amaral; Aixia Sun; Yilin Li; Chao Ren; Anh Truong; Zexu Jiao; Ping Wang; Chao Zhou

doi:10.1117/12.2652950

8 March 2023 Characterization of age-related follicle changes in mice ovaries using optical coherence tomography

Marcello Amaral, Aixia Sun, Yilin Li, Chao Ren, Anh Truong, Zexu Jiao, Ping Wang, Chao Zhou

Proceedings Volume 12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; 123670X (2023) https://doi.org/10.1117/12.2652950
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Ovarian tissue cryopreservation is used to frozen preserve ovary tissue for reimplantation, potentially restoring a cancer patient’s fertility after chemo and/or radiation treatment. The selection of ovary tissue containing many primordial and secondary follicles for reimplantation increases the probability of pregnancy, but it is a challenging task. In this work, we used spectral-domain OCT to evaluate the feasibility of non-invasively characterizing the morphology of ovary follicle development and age-related modifications in mice. The measured dimension and agerelated number of follicles presented a good agreement with corresponding histological images, demonstrating the potential to use OCT to evaluate ovary tissue for reimplantation.

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Citation Download Citation

Marcello Amaral, Aixia Sun, Yilin Li, Chao Ren, Anh Truong, Zexu Jiao, Ping Wang, and Chao Zhou "Characterization of age-related follicle changes in mice ovaries using optical coherence tomography", Proc. SPIE 12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, 123670X (8 March 2023); https://doi.org/10.1117/12.2652950

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