Closed-loop contrast source regulation through real-time spectroscopic photoacoustic imaging: phantom evaluation

Ryo Murakami; Shang Gao; Haichong K. Zhang

doi:10.1117/12.2648007

9 March 2023 Closed-loop contrast source regulation through real-time spectroscopic photoacoustic imaging: phantom evaluation

Ryo Murakami, Shang Gao, Haichong K. Zhang

Author Affiliations +

Proceedings Volume 12379, Photons Plus Ultrasound: Imaging and Sensing 2023; 1237919 (2023) https://doi.org/10.1117/12.2648007
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Photoacoutisc (PA) imaging can not only depict the geometrical features of a target like ultrasound but also allow to decompose of the contribution from different material sources based on their own specific optical absorption characteristics. With the potential of PA imaging, how to utilize the extracted information beyond diagnosis and monitoring is an open research question. Despite this interest in the field, the PA-based automation of regulating conditions of contrast sources such as position and concentration has not been actively studied. This regulation has the potential to be used for several applications including precise/long-term dose control of exogenous contrast agents in the context of drug delivery. In addition, material decomposition allows for the selective regulation of specific contrast agents. This would be advantageous in clinical situations where it is necessary to use multiple types of contrast agents simultaneously and independently. In this report, we propose a system architecture to realize closed-loop source regulation through real-time spectroscopic PA imaging and develop an experimental setup to demonstrate the feasibility of this approach. The system autonomously terminated the ICG flow within the target performance range which is defined considering the specifications of the system.

Citation Download Citation

Ryo Murakami, Shang Gao, and Haichong K. Zhang "Closed-loop contrast source regulation through real-time spectroscopic photoacoustic imaging: phantom evaluation", Proc. SPIE 12379, Photons Plus Ultrasound: Imaging and Sensing 2023, 1237919 (9 March 2023); https://doi.org/10.1117/12.2648007

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