Dual encapsulated dacarbazine and indocyanine green in hyaluronic acid-coated liposomes for actively targeted treatment of melanoma by combined therapy

Yihan Lu

doi:10.1117/12.2660528

6 December 2022 Dual encapsulated dacarbazine and indocyanine green in hyaluronic acid-coated liposomes for actively targeted treatment of melanoma by combined therapy

Yihan Lu

Author Affiliations +

Proceedings Volume 12458, International Conference on Biomedical and Intelligent Systems (IC-BIS 2022); 124580E (2022) https://doi.org/10.1117/12.2660528
Event: International Conference on Biomedical and Intelligent Systems, 2022, Chengdu, China

Abstract

A novel method for treating melanoma which is a fatal skin cancer is proposed in this article. By combining chemotherapy and photodynamic therapy (PDT), it provides us a more effective and efficient way for the treatment of melanoma. The dacarbazine which is reported to be a relatively mild drug in inhibiting melanoma is combined with the indocyanine green that can be used as a photosensitizer for PDT to realize the combined therapy. Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC) and 1,2-Dioleoyl-3-trimethylammonium-propan (DOTAP) was used to synthesize the liposomes which gave it a positively charged surface for electrostatic coating with hyaluronic acid. Hyaluronic acid molecules are utilized to modify the liposomes surface to achieve the purpose of active targeting to the melanoma sites. This nanoparticle is expected to show enhanced cytotoxicity and its therapeutic effect compared with regular treatment against melanoma.

Citation Download Citation

Yihan Lu "Dual encapsulated dacarbazine and indocyanine green in hyaluronic acid-coated liposomes for actively targeted treatment of melanoma by combined therapy", Proc. SPIE 12458, International Conference on Biomedical and Intelligent Systems (IC-BIS 2022), 124580E (6 December 2022); https://doi.org/10.1117/12.2660528

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available