In vivo endoscopic polarization sensitive optical coherence tomography for the quantification of airway smooth muscle in severe asthma and healthy volunteers

T. Soldati; M. Vaselli; P. C. Wijsman; S. M. Vassileva; J. T. Annema; P. I. Bonta; J. F. de Boer

doi:10.1117/12.2670947

11 August 2023 In vivo endoscopic polarization sensitive optical coherence tomography for the quantification of airway smooth muscle in severe asthma and healthy volunteers

T. Soldati, M. Vaselli, P. C. Wijsman, S. M. Vassileva, J. T. Annema, P. I. Bonta, J. F. de Boer

Author Affiliations +

Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 126320A (2023) https://doi.org/10.1117/12.2670947
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Asthma is an inflammatory disease, causing thickening of the Airway Smooth Muscle (ASM). No current method exists to directly measure ASM within a living patient. Endoscopic Polarization Sensitive Optical Coherence Tomography (PS-OCT) might enable quantification of ASM mass in vivo, by assessing tissue birefringence. We performed in vivo PS-OCT on severe asthma patients and healthy volunteers, with an in-house built distal scanning catheter (1.35 mm), to circumferentially scan the airways at 52 fps B-scan rate. We provided the first comparison of in vivo PS-OCT images between asthma and healthy subjects and demonstrated the ability of PS-OCT to assess ASM content.

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T. Soldati, M. Vaselli, P. C. Wijsman, S. M. Vassileva, J. T. Annema, P. I. Bonta, and J. F. de Boer "In vivo endoscopic polarization sensitive optical coherence tomography for the quantification of airway smooth muscle in severe asthma and healthy volunteers", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 126320A (11 August 2023); https://doi.org/10.1117/12.2670947

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