Bioinspired nano-optical metasurfaces for histopathology

Paula Kirya; Samantha Bordy; Kaylani Patel; Zaid Haddadin; Omonigho Aisagbonhi; Lisa Poulikakos

doi:10.1117/12.2677836

4 October 2023 Bioinspired nano-optical metasurfaces for histopathology

Paula Kirya, Samantha Bordy, Kaylani Patel, Zaid Haddadin, Omonigho Aisagbonhi, Lisa Poulikakos

Proceedings Volume 12693, Unconventional Imaging, Sensing, and Adaptive Optics 2023; 126931C (2023) https://doi.org/10.1117/12.2677836
Event: SPIE Optical Engineering + Applications, 2023, San Diego, California, United States

Abstract

Fibrotic diseases account for one-third of deaths worldwide, making it essential to investigate the accompanying tissue microstructural changes that are critical to disease progression. This research focuses on the fibrotic extracellular matrices present in histological tissue sections, which can characterize disease progression. We demonstrate how bioinspired structural color can be utilized as a label-free technology to determine disease progression on a single nanostructured surface. This nanophotonic imaging platform characterizes the organization of fibrous biological tissues with distinct stain-free color responses. The colorimetric response of histological tissue sections interfaced with these nanostructured slides was quantitatively assessed.

Conference Presentation

Citation Download Citation

Paula Kirya, Samantha Bordy, Kaylani Patel, Zaid Haddadin, Omonigho Aisagbonhi, and Lisa Poulikakos "Bioinspired nano-optical metasurfaces for histopathology", Proc. SPIE 12693, Unconventional Imaging, Sensing, and Adaptive Optics 2023, 126931C (4 October 2023); https://doi.org/10.1117/12.2677836

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