X-ray digital radiography and fluorescence dual-modality Fourier single-pixel imaging for small animals

Zhuoyao Huang; Xiaoquan Yang; Jie Zhang; Hui Gong

doi:10.1117/12.2686162

29 November 2023 X-ray digital radiography and fluorescence dual-modality Fourier single-pixel imaging for small animals

Zhuoyao Huang, Xiaoquan Yang, Jie Zhang, Hui Gong

Author Affiliations +

Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 127701P (2023) https://doi.org/10.1117/12.2686162
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Conference Poster

Abstract

X-ray digital radiography and fluorescence dual-modality imaging system has become an important tool for in-vivo biomedical researches. However, current dual-modality imaging system generally employs two independent pixelated detectors, which is costly and bulky. Here we propose a novel approach to achieve dual-modality imaging system utilizing only one single-pixel detector. The prototype of the system is built based on a Fourier single-pixel imaging architecture. The spatial resolution of the X-ray digital radiography modality was measured to be 1.81mm, the sensitivity and the imaging depth of the fluorescence imaging modality was evaluated to be 1.48 nmol/ml and 4 mm, respectively. Compared with the conventional system, our system is cost affordable, with a more compact structure, and free of image registration from different modalities. In-vivo imaging results of a C57BL/6 female mouse bearing tumor targeted with mCherry demonstrates its capability for small animal researches.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Zhuoyao Huang, Xiaoquan Yang, Jie Zhang, and Hui Gong "X-ray digital radiography and fluorescence dual-modality Fourier single-pixel imaging for small animals", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 127701P (29 November 2023); https://doi.org/10.1117/12.2686162

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