Large depth-of-field and high-resolution optical coherence tomography angiography with a needle-shaped beam

Xiangyu Guo; Jingjing Zhao; Adam de la Zerda; Liqun Sun

doi:10.1117/12.2686500

27 November 2023 Large depth-of-field and high-resolution optical coherence tomography angiography with a needle-shaped beam

Xiangyu Guo, Jingjing Zhao, Adam de la Zerda, Liqun Sun

Author Affiliations +

Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 127701V (2023) https://doi.org/10.1117/12.2686500
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Conference Poster

Abstract

Optical coherence tomography angiography (OCTA) has emerged as a highly competitive technique for visualizing blood perfusion without the need for exogenous contrast agents. However, for high-resolution optical imaging, a tight optical focus is usually needed to achieve the diffraction-limited resolution in optical microscopy, which results in a limited depth of field (DOF), making it challenging to obtain large-scale, non-stitched, high-resolution images of samples with uneven surfaces without performing Z-axis scanning. To solve this problem, we introduce the diffractive optical elements (DOEs) into the conventional Gaussian beam (GB) OCT system and develop a needle-shaped beam (NB) OCT system with both long DOF and high resolution, which maintains 8 μm lateral resolution over a depth range of 620 μm, allowing real-time, non-stitched, large-field imaging of samples with uneven surfaces. OCTA imaging of mouse brains with natural curvature was demonstrated in our work.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Xiangyu Guo, Jingjing Zhao, Adam de la Zerda, and Liqun Sun "Large depth-of-field and high-resolution optical coherence tomography angiography with a needle-shaped beam", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 127701V (27 November 2023); https://doi.org/10.1117/12.2686500

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