Clinical application of proteolysis targeting chimeras

Jinfeng Gao; Chuhan Meng; Vivian FT Yuan

doi:10.1117/12.3000206

7 September 2023 Clinical application of proteolysis targeting chimeras

Jinfeng Gao, Chuhan Meng, Vivian FT Yuan

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127891M (2023) https://doi.org/10.1117/12.3000206
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Targeted protein degradation is one of the key research topics today. Proteolysis targeting chimeric (PROTAC) are heterobifunctional molecules that aim to eliminate disease-causing proteins by degradation. A number of PROTACs have initiated phase I or II clinical trials to treat many kinds of cancers and some other diseases, but there is no PROTAC drug on the market worldwide now. In this paper, the clinical application and safety of PROTACs in trials were explored by collecting relevant data of clinical trials and analyzing the available results. Some PROTACs have already showed beneficial effects for patients with a favorable safety profile in clinical trials. However, there are still many difficulties with PROTAC technology that need to be solved in the future such as low membrane permeability and the lag in the development of E3 ligands. Currently, another degradation technology called PROTAB was designed to promote effective ubiquitination and breakdown of transmembrane proteins and its future potential is just as great as PROTACs.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Jinfeng Gao, Chuhan Meng, and Vivian FT Yuan "Clinical application of proteolysis targeting chimeras", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127891M (7 September 2023); https://doi.org/10.1117/12.3000206

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