Novel pharmaceutical approaches targeting antibiotic resistance

Yuqi Zhang

doi:10.1117/12.2691858

7 September 2023 Novel pharmaceutical approaches targeting antibiotic resistance

Yuqi Zhang

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127892P (2023) https://doi.org/10.1117/12.2691858
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Since the discovery of antibiotics in 1929, antibiotics have played a pivotal role in clinical health care. However, with the widespread use of antibiotics, certain bacteria have acquired antibiotic resistance. Antibiotic resistance has become a global crisis. In this paper, we reviewed the mechanism for bacteria developing antibiotic resistance, and focus on novel treatments than can counteract bacterial resistance, including new-class antibiotics and antibody-based therapies. Chimeric peptidomimetic antibiotics, Darobactin and Lugdunin are recently identified compounds that are able to prevent or eliminate bacteria. Despite that the aim is to either act as bactericidal or toxin neutralizing antibodies, all three monoclonal antibodies that are approved for treatment of specific bacterial infection, exert actions by neutralizing released toxin. The aim is to introduce antibiotics or therapy battling infection but with low resistance tendency. Overall, investigations on developing new therapies against antibiotic resistance are warranted, especially therapies with little side effects or a direct bactericidal action.

Citation Download Citation

Yuqi Zhang "Novel pharmaceutical approaches targeting antibiotic resistance", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127892P (7 September 2023); https://doi.org/10.1117/12.2691858

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