Detection of atherosclerotic plaques with nanoparticles as contrast agent using a multimodal imaging system

Rouyan Chen; Lauren Sandeman; Victoria Nankivell; Joanne T. M. Tan; Gang Zheng; Peter J. Psaltis; Christina Bursill; Robert A. McLaughlin; Jiawen Li

doi:10.1117/12.3000277

13 March 2024 Detection of atherosclerotic plaques with nanoparticles as contrast agent using a multimodal imaging system

Rouyan Chen, Lauren Sandeman, Victoria Nankivell, Joanne T. M. Tan, Gang Zheng, Peter J. Psaltis, Christina Bursill, Robert A. McLaughlin, Jiawen Li

Author Affiliations +

Proceedings Volume 12819, Diagnostic and Therapeutic Applications of Light in Cardiology 2024; 128190A (2024) https://doi.org/10.1117/12.3000277
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Atherosclerosis is a leading cause of global mortality. Current clinically available imaging techniques suffer from limited spatial resolution and lack the ability to identify biomolecular features of atherosclerotic plaques. To address this, our team has developed a bimodal imaging system which consists of optical coherence tomography (OCT) and fluorescence. In addition, a nanoparticle named porphysomes is used as a fluorescence contrast agent to target macrophages in the plaques of diseased mice. Results suggest that our intravascular imaging system is capable of detecting the fluorescence from nanoparticles which provides complementary biological information to the structural information obtained from simultaneously-acquired OCT images.

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Rouyan Chen, Lauren Sandeman, Victoria Nankivell, Joanne T. M. Tan, Gang Zheng, Peter J. Psaltis, Christina Bursill, Robert A. McLaughlin, and Jiawen Li "Detection of atherosclerotic plaques with nanoparticles as contrast agent using a multimodal imaging system", Proc. SPIE 12819, Diagnostic and Therapeutic Applications of Light in Cardiology 2024, 128190A (13 March 2024); https://doi.org/10.1117/12.3000277

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