Super-resolution optical coherence tomography for biomedical applications

Pauline John; Azhar Zam

doi:10.1117/12.3005754

12 March 2024 Super-resolution optical coherence tomography for biomedical applications

Pauline John, Azhar Zam

Proceedings Volume 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; 128300J (2024) https://doi.org/10.1117/12.3005754
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Optical coherence tomography (OCT) is a non-invasive, label-free, depth-resolved imaging and diagnostic technique with eclectic applications in medical and industrial domains. The typical resolution of structural changes detected by conventional depth-resolved OCT technique is about 1 to 15μm. Detection of nanoscale structural changes of biological tissues, aids in functional imaging of pathological processes which is not possible to detect using conventional intensity based OCT technique. The detection of biological tissues in nanoscale order is addressed in this work, using a SLED source of centre wavelength 930nm, a bandwidth of 102nm and a wavelength range of 874nm to 1027nm. This method helps in retaining high spatial frequency information and visualizing the structural changes occurring in biological tissues with spatial periods between 291nm to 343nm, without the need for excision as in the case of histological examination of morphological changes in the ultra-structures of biological tissues. A difference of 5 to 10nm in the spatial periods of biological structures were clearly observed from the nanosensitive OCT (nsOCT) results of in vivo nail and finger tissues.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Pauline John and Azhar Zam "Super-resolution optical coherence tomography for biomedical applications", Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 128300J (12 March 2024); https://doi.org/10.1117/12.3005754

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