Submillimeter robotic OCT neuroendoscope for deep-brain imaging in vivo

Chao Xu; Zhiwei Fang; Tinghua Zhang; Huxin Gao; Tao Zhang; Peng Liu; Hongliang Ren; Wu Yuan

doi:10.1117/12.3000678

12 March 2024 Submillimeter robotic OCT neuroendoscope for deep-brain imaging in vivo

Chao Xu, Zhiwei Fang, Tinghua Zhang, Huxin Gao, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan

Proceedings Volume 12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII; 1283103 (2024) https://doi.org/10.1117/12.3000678
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

To effectively manage inoperable deep-seated brain diseases, a high-resolution diminutive endoscope is required. This endoscope should be capable of precisely localizing and evaluating lesions in vivo. In this study, we introduce an ultrathin robotic OCT neuroendoscope designed for minimally invasive and targeted imaging in the deep brain. The neuroendoscope, measuring only 0.6mm in diameter, is fabricated by coupling a custom micro-lens on the fiber tip. This fabrication technique enables high resolution imaging of 2.4μm × 4.5μm in the axial and transverse directions. To ensure precise trajectory planning and accurate lesion localization within the brain, we have developed a skull-mounted robotic neuroendoscope positioner, allowing for a localization accuracy of approximately 1mm. To demonstrate the capabilities of our technology, we have utilized electromagnetic tracking technology to enable us to control and navigate the neuroendoscope, allowing for the precise localization and imaging of targets within a brain phantom. The new technology holds significant potential to translate OCT neuroendoscopy into clinical practice for deep brain conditions.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Chao Xu, Zhiwei Fang, Tinghua Zhang, Huxin Gao, Tao Zhang, Peng Liu, Hongliang Ren, and Wu Yuan "Submillimeter robotic OCT neuroendoscope for deep-brain imaging in vivo", Proc. SPIE 12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII, 1283103 (12 March 2024); https://doi.org/10.1117/12.3000678

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical coherence tomography

Robotics

In vivo imaging

Brain

Endoscopes

Imaging systems

Neuroimaging

Show All Keywords

Keywords/Phrases

Search In:

Publication Years