Autofluorescence imaging of sporadic and basal cell nevus syndrome-associated basal cell carcinomas

Emilija V. Plorina; Alexey Lihachev; Norbert Kiss; Dmitrijs Bliznuks; Ilze Lihacova; Andras Banvolgyi

doi:10.1117/12.3017449

18 June 2024 Autofluorescence imaging of sporadic and basal cell nevus syndrome-associated basal cell carcinomas

Emilija V. Plorina, Alexey Lihachev, Norbert Kiss, Dmitrijs Bliznuks, Ilze Lihacova, Andras Banvolgyi

Proceedings Volume 13009, Clinical Biophotonics III; 130090B (2024) https://doi.org/10.1117/12.3017449
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

There is a need for a noninvasive diagnostic method for early detection of basal cell carcinoma which is the most common type of cancer in the general population. Basal cell nevus syndrome is a rare autosomal dominant disorder that increases predisposition to basal cell carcinoma, with a lower average age of onset and a higher number of lesions. Autofluorescence and autofluorescence photobleaching imaging is a potential approach to early diagnosis and determining whether an aggressive form of basal cell carcinoma is present earlier, however, the mechanism is still not fully understood. Investigation of basal cell nevus syndrome associated basal cell carcinoma autofluorescence intensity and autofluorescence photobleaching kinetics could assist in early detection and assessment of basal cell carcinoma in general.

An imaging device with 405 nm LED illumination at power density 7 mW/cm² was used for cutaneous autofluorescence excitation. Autofluorescence photobleaching was detected by imaging under continuous irradiation for 20 seconds. It was found that on average basal cell carcinoma in patients with basal cell nevus syndrome has a lower autofluorescence intensity at the first second of excitation, as well as smaller decrease in intensity after 20 seconds of irradiation compared to sporadic basal cell carcinoma. This may show that basal cell carcinoma in patients with basal cell nevus syndrome have a different composition of endogenous fluorophores than in sporadic cases which could be investigated in further research.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Emilija V. Plorina, Alexey Lihachev, Norbert Kiss, Dmitrijs Bliznuks, Ilze Lihacova, and Andras Banvolgyi "Autofluorescence imaging of sporadic and basal cell nevus syndrome-associated basal cell carcinomas", Proc. SPIE 13009, Clinical Biophotonics III, 130090B (18 June 2024); https://doi.org/10.1117/12.3017449

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available