Advancements in pathogen detection: the integration of SERS and LSPR technologies in handheld clinical diagnostics

Sebastian Huelck

doi:10.1117/12.3022222

6 June 2024 Advancements in pathogen detection: the integration of SERS and LSPR technologies in handheld clinical diagnostics

Sebastian Huelck

Author Affiliations +

Proceedings Volume 13059, Smart Biomedical and Physiological Sensor Technology XXI; 130590E (2024) https://doi.org/10.1117/12.3022222
Event: SPIE Defense + Commercial Sensing, 2024, National Harbor, Maryland, United States

Conference Poster

Abstract

Amid the SARS-CoV-2 pandemic, traditional virus detection methods like RT-qPCR face limitations in terms of infrastructure and processing time. This has spurred the development of agile diagnostic technologies, emphasizing non-invasive and rapid testing. Surface-Enhanced Raman Scattering (SERS) and Localized Surface Plasmon Resonance (LSPR) have emerged as promising alternatives. SERS, amplifying Raman signals through metal nanostructures, offers high sensitivity, high specificity, rapid response, qualitative and quantitative analysis enhanced by recent innovations like multiwell-array substrates. Integration with machine learning refines SERS's diagnostic capabilities, enabling rapid and accurate identification of SARS-CoV-2. LSPR, leveraging light-metal nanoparticle interactions, revolutionizes rapid viral detection, especially with the development of portable handheld devices. These devices enable real-time, on-site testing, proving crucial in managing infectious disease outbreaks. Their applications extend beyond SARS-CoV-2, holding potential for various pathogens.

Citation Download Citation

Sebastian Huelck "Advancements in pathogen detection: the integration of SERS and LSPR technologies in handheld clinical diagnostics", Proc. SPIE 13059, Smart Biomedical and Physiological Sensor Technology XXI, 130590E (6 June 2024); https://doi.org/10.1117/12.3022222

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available