Detection and confirmation of Salmonella Typhimurium by smartphone-enabled optomechanical platform

Hyun Jung Min; Hansel A. Mina; Sungho Shin; Iyll-Joon Doh; J. Paul Robinson; Bartek Rajwa; Amanda J. Deering; Euiwon Bae

doi:10.1117/12.3016099

6 June 2024 Detection and confirmation of Salmonella Typhimurium by smartphone-enabled optomechanical platform

Hyun Jung Min, Hansel A. Mina, Sungho Shin, Iyll-Joon Doh, J. Paul Robinson, Bartek Rajwa, Amanda J. Deering, Euiwon Bae

Author Affiliations +

Proceedings Volume 13060, Sensing for Agriculture and Food Quality and Safety XVI; 130600H (2024) https://doi.org/10.1117/12.3016099
Event: SPIE Defense + Commercial Sensing, 2024, National Harbor, Maryland, United States

Conference Poster

Abstract

Salmonella ser. Typhimurium is notorious for causing serious foodborne illnesses and presenting considerable public health risks. The study introduces an innovative system based on a quartz crystal microbalance, designed to detect the target pathogen by integrating the system around a smartphone. The system operates through a dual-mode approach, relying on two distinct mechanisms: measuring frequency changes due to variations in bacterial mass and quantifying fluorescence intensities resulting from bacteria captured by FITC-labeled antibodies. Incorporating FITC-labeled antibodies not only enhances the resonance frequency shift but also offers visual confirmation through the fluorescence signal. The integration of the quartz crystal microbalance system with a smartphone enables real-time monitoring. This system displays both frequency and temperature data, while also capturing fluorescence intensities to estimate the concentration of the target analyte. The smartphone-based system successfully detected Salmonella Typhimurium within a concentration range of 10⁵ CFU/mL after the application of FITC-labeled antibodies. This portable QCM system represents a promising advancement in pathogen detection, holding significant potential to improve food safety protocols and strengthen public health safeguards.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Hyun Jung Min, Hansel A. Mina, Sungho Shin, Iyll-Joon Doh, J. Paul Robinson, Bartek Rajwa, Amanda J. Deering, and Euiwon Bae "Detection and confirmation of Salmonella Typhimurium by smartphone-enabled optomechanical platform", Proc. SPIE 13060, Sensing for Agriculture and Food Quality and Safety XVI, 130600H (6 June 2024); https://doi.org/10.1117/12.3016099

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