Centrifugal microfluidic chip for multistep fluid control at low rotational speed

Shuyu Lu; Yuanzhan Yang; Siqi Cui; Anyi Li; Xiaoqiong Li

doi:10.1117/12.3044365

27 August 2024 Centrifugal microfluidic chip for multistep fluid control at low rotational speed

Shuyu Lu, Yuanzhan Yang, Siqi Cui, Anyi Li, Xiaoqiong Li

Proceedings Volume 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024); 1325222 (2024) https://doi.org/10.1117/12.3044365
Event: 2024 Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 2024, Kaifeng, China

Abstract

Centrifugal microfluidic chips have excellent automation potential. Various detection technologies have been integrated into centrifugal microfluidic chips. To realize multi-step reaction processes, centrifugal microfluidic chips require the integration of several valves. Valve systems using only capillary valves may lead to excessively high rotational speeds. This is undesirable for manufacturing portable, low-power centrifugal microfluidic chip mating devices. Through valve mating and chamber layout, a valve system with low rotational speed characteristics was designed to overcome the dependence of centrifugal microfluidic chips on high rotational speed. The system includes 2 hydrophobic valves, 2 siphon valves and a Coriolis force structure. This study simulated the parametrically designed valve and Coriolis force structure by COMSOL and obtained the liquid control effect as expected. Using fluid simulation, the development cycle of the centrifugal microfluidic chip was shortened, saving time and expense. Through experiments, this study proved that our centrifugal microfluidic chip can accomplish 4-step reaction and 7-step pipetting control of 5 reagents. It has consistency and stability for the distribution of products.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Shuyu Lu, Yuanzhan Yang, Siqi Cui, Anyi Li, and Xiaoqiong Li "Centrifugal microfluidic chip for multistep fluid control at low rotational speed", Proc. SPIE 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 1325222 (27 August 2024); https://doi.org/10.1117/12.3044365

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