Photodynamic therapy in two murine tumor models with sulfonated aluminum phthalocyanine

Hong-Yu Yu; Rong-Chun Dong; Ji-Yao Chen; Huai-Xin Cai

doi:10.1117/12.137032

5 March 1993 Photodynamic therapy in two murine tumor models with sulfonated aluminum phthalocyanine

Hong-Yu Yu, Rong-Chun Dong, Ji-Yao Chen, Huai-Xin Cai

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137032
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

Photodynamic therapy (PDT) with sulfonated aluminum phthalocyanine (AlSPC), i.e., AlSPC-PDT, in two murine tumor models is reported here. The encouraging therapy results were observed in S₁₈₀ fibrosarcoma transplanted in white mice of the Kunming line and in human hepatocellular carcinoma transplanted in balb/c nu/nu nude mice. The experimental tumors in the mice were chosen of those 0.5 - 0.8 cm in diameter and 0.4 - 0.7 cm in thickness. Photofrin II (PII) and Photosensitizing drug-007 (PSD-007), two kinds of porphyrin derivative dyes, were chosen as the contrast photosensitizers of AlSPC. A dose of 10 mg/kg AlSPC or PII or PSD-007 was given (iv). The dose of light (600 - 750 nm) was 180 J/cm². `Cure (short-term)' was defined as regression of neoplastic tissue to a non-palpable tumor within 14 days after PDT. `Cure (long-term)' was defined as absence of local tumor tissue and tumor metastasis on gross and microscopic examinations within 107 days after PDT. The curative results suggest that AlSPC may be a more effective sensitizer than both PII and PSD-007.

Citation Download Citation

Hong-Yu Yu, Rong-Chun Dong, Ji-Yao Chen, and Huai-Xin Cai "Photodynamic therapy in two murine tumor models with sulfonated aluminum phthalocyanine", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137032

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