Biodistribution detection of Photofrin porfimer sodium and benzoporphyrin derivative using a fiber optic sensor and ratio fluorometry

Sandor G. Vari M.D.; Theodore G. Papazoglou; Thanassis Papaioannou; Marigo Stavridi; Vani R. Pergadia; Michael C. Fishbein M.D.; Maurits J. van der Veen; Reem Thomas; Warren S. Grundfest M.D.

doi:10.1117/12.168656

1 March 1994 Biodistribution detection of Photofrin porfimer sodium and benzoporphyrin derivative using a fiber optic sensor and ratio fluorometry

Sandor G. Vari M.D., Theodore G. Papazoglou, Thanassis Papaioannou, Marigo Stavridi, Vani R. Pergadia, Michael C. Fishbein M.D., Maurits J. van der Veen, Reem Thomas, Warren S. Grundfest M.D.

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168656
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Laser induced fluorescence spectroscopy (LIFS) was used to detect the presence of PHOTOFRIN^R porfimer sodium and Benzoporphyrin derivative-monoacid, ring A (BPD-MA) in various tissues. Lobund Wistar rats (n equals 49) inoculated with rat prostatic adenocarcinoma (PA-III) were injected with PHOTOFRIN^R porfimer sodium (7.5 - 0.25 mg/kg) and BPD (0.50 - 25 mg/kg) intravenously. A Helium-Cadmium laser (442 nm) was used as an excitation source. Our study showed that the amount of PHOTOFRIN^R porfimer sodium and BPD-MA which localizes in the metastatic lymph nodes is higher than in tumor and all other healthy tissues. Laser induced fluorescence spectroscopy may be a feasible method to detect the distribution of photosensitizers or other fluorescent compounds in vivo.

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Sandor G. Vari M.D., Theodore G. Papazoglou, Thanassis Papaioannou, Marigo Stavridi, Vani R. Pergadia, Michael C. Fishbein M.D., Maurits J. van der Veen, Reem Thomas, and Warren S. Grundfest M.D. "Biodistribution detection of Photofrin porfimer sodium and benzoporphyrin derivative using a fiber optic sensor and ratio fluorometry", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168656

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