Synthesis of axially disubstituted octakis-alkoxy-germanium(IV) phthalocyanines

M. E. Baumann; Hans-Georg Capraro; Rolf Hilfinker; Martin Ochsner

doi:10.1117/12.168688

1 March 1994 Synthesis of axially disubstituted octakis-alkoxy-germanium(IV) phthalocyanines

M. E. Baumann, Hans-Georg Capraro, Rolf Hilfinker, Martin Ochsner

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168688
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

A series of new octakis-substituted Germanium-phthalocyanines for use in photodynamic therapy of tumors has been synthesized. Starting from 1,4-dialkoxy-2,3-dicyano-benzene the metal-free octakis-alkoxy-phthalocyanine 13 was prepared. The metallation to the corresponding octakis-alkoxy-GeCl₂-phthalocyanine 15 was done with a GeCl₄-DMF complex. Alkaline hydrolysis gave quantitatively the octakis-alkoxy-Ge(OH)₂- phthalocyanine 16. By substitution of the hydroxy groups with alcohols, thiols and silanols the axially disubstituted phthalocyanines were obtained. The most important photophysical properties for PDT (Q-bands, singlet oxygen quantum yields and (Phi) _f) are reported.

Citation Download Citation

M. E. Baumann, Hans-Georg Capraro, Rolf Hilfinker, and Martin Ochsner "Synthesis of axially disubstituted octakis-alkoxy-germanium(IV) phthalocyanines", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168688

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