Comparison of Ti:sapphire laser and excimer-laser-pumped dye laser for PDT with Zn(II)-phthalocyanine

Volkhard Abraham; Stefan B. Spaniol; Birgit C. Schultes; Stephan Schmidt; Wolfgang Ertmer

doi:10.1117/12.179971

19 July 1994 Comparison of Ti:sapphire laser and excimer-laser-pumped dye laser for PDT with Zn(II)-phthalocyanine

Volkhard Abraham, Stefan B. Spaniol, Birgit C. Schultes, Stephan Schmidt, Wolfgang Ertmer

Proceedings Volume 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III; (1994) https://doi.org/10.1117/12.179971
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

We compared the photodynamic efficiency of pulsed to cw laser irradiation in a cell culture experiment with a NIH ovarian cancer cell line (NIH-OVCAR3). Our photosensitizer was a cationic Zn(II)-phthalocyanine with an absorption maximum near 675 nm. The laser systems we use are an excimer laser pumped DCM-dye laser ((tau) equals 15 ns) and a cw Ti:sapphire laser. The photodynamic activity of the photosensitizer strongly depends on the pulse fluence and decreases with increasing fluence due to saturation of the sensitizer. In another experiment no changes in the light penetration depth into the tissue for pulsed irradiation could be detected up to a pulse intensity of 3 MW/cm².

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Volkhard Abraham, Stefan B. Spaniol, Birgit C. Schultes, Stephan Schmidt, and Wolfgang Ertmer "Comparison of Ti:sapphire laser and excimer-laser-pumped dye laser for PDT with Zn(II)-phthalocyanine", Proc. SPIE 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III, (19 July 1994); https://doi.org/10.1117/12.179971

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KEYWORDS

Absorption

Dye lasers

Excimer lasers

Pulsed laser operation

Tissue optics

Photodynamic therapy

Sapphire lasers

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