Two-dimensional computer simulations for real-time irradiation planning of laser-induced interstitial thermotherapy (LITT)

Andre Roggan; Gerhard J. Mueller

doi:10.1117/12.197569

23 December 1994 Two-dimensional computer simulations for real-time irradiation planning of laser-induced interstitial thermotherapy (LITT)

Andre Roggan, Gerhard J. Mueller

Author Affiliations +

Proceedings Volume 2327, Medical Applications of Lasers II; (1994) https://doi.org/10.1117/12.197569
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

A computer model is presented enabling the determination of optimized laser parameters in advance of a LITT treatment. Besides, a real-time simulation of the spatial temperature- and damage distribution can be performed during the treatment. Input parameters for the simulation are the specific optical and thermal properties of the tissue. The optical properties of human liver and human prostate were measured at 850 nm and 1064 nm using a double- integrating sphere technique and inverse Monte-Carlo simulations. The thermal tissue properties were calculated from the individual water contents. The calculation of the spatial intensity distribution is carried out by performing a fast three-dimensional Monte-Carlo simulation in small time steps. The change of the optical tissue properties during the process of coagulation is taken into account. The corresponding temperature distribution is calculated by a numerical solution of the two-dimensional bio-heat transport equation in cylindrical geometry. Finally the degree of tissue damage is determined by solving the Arrhenius formulas numerically. Blood perfusion of the tissue can be considered as an internal cooling effect. Comparison of the calculated temperature behavior with experimental data shows good agreement.

Citation Download Citation

Andre Roggan and Gerhard J. Mueller "Two-dimensional computer simulations for real-time irradiation planning of laser-induced interstitial thermotherapy (LITT)", Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); https://doi.org/10.1117/12.197569

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