Effectiveness of photodynamic therapy with a diode laser using mono-L-aspartyl chlorin e6 for implanted fibrosarcoma in mice

Tohichiro Katsumi; Katsuo Aizawa; Yukari Kuroiwa; Yoshiteru Ii; Kouichi Saito; X. Ilyar; Tetsuya Okunaka; Chimori Konaka; Harubumi Kato M.D.

doi:10.1117/12.203430

1 March 1995 Effectiveness of photodynamic therapy with a diode laser using mono-L-aspartyl chlorin e6 for implanted fibrosarcoma in mice

Tohichiro Katsumi, Katsuo Aizawa, Yukari Kuroiwa, Yoshiteru Ii, Kouichi Saito, X. Ilyar, Tetsuya Okunaka, Chimori Konaka, Harubumi Kato M.D.

Author Affiliations +

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203430
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

The authors developed a new high power red laser diode system for photodynamic therapy (PDT) with Mono-L-aspartyl Chlorin e6 (NPe6). The laser beam has a low wavelength (664 nm) and relatively high power. Our results suggest that a certain increase in the tumor tissue level of NPe6 and a certain increase of laser light dose reaching a deeper layer of tumor caused an increase in percent cure. In addition, the effectiveness of PDT and also tumor recurrence following PDT depend to some extent on the total laser dose reaching deeper layers of tumors. Furthermore, the effectiveness of PDT tends to correlate with the amount of photobleaching by PDT.

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Tohichiro Katsumi, Katsuo Aizawa, Yukari Kuroiwa, Yoshiteru Ii, Kouichi Saito, X. Ilyar, Tetsuya Okunaka, Chimori Konaka, and Harubumi Kato M.D. "Effectiveness of photodynamic therapy with a diode laser using mono-L-aspartyl chlorin e6 for implanted fibrosarcoma in mice", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203430

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