Photodynamic therapy (PDT) for perianal bowenoid papulosis

Johannes Gahlen; Josef Stern; Georgi Graschew; Michael R. Kaus; W. Tilgen

doi:10.1117/12.203408

1 March 1995 Photodynamic therapy (PDT) for perianal bowenoid papulosis

Johannes Gahlen, Josef Stern, Georgi Graschew, Michael R. Kaus, W. Tilgen

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203408
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

HPV associated bowenoid papulosis of the anogenital region are classified as carcinoma in situ. The treatment can be difficult and recurrence rates are high. Extended surgical resections may have complications such as anal sphincter insufficiency. PDT does have some advantages and less side effects in the treatment of these tumors. We treated one female patient with an extended perianal bowenoid papulosis. Previous surgical resection led to local recurrence and partial sphincter insufficiency. Twenty-four hours before local laser light radiation (Ar-Dye laser, 630 nm wavelength), a systemic photosensitizer was applied (Photofrin II, 1.5 mg/kg BW). Four courses of PDT were performed within one year. We observed a total tumor necrosis in every radiation area. The previous sphincter insufficiency improved during the sessions. Side effects were rare. Pain in the radiation was stopped within 2 - 3 days under pain medication. PDT can induce a total local tumor necrosis in perianal bowenoid papulosis. Concerning local expansion, PDT can be a curable treatment.

Citation Download Citation

Johannes Gahlen, Josef Stern, Georgi Graschew, Michael R. Kaus, and W. Tilgen "Photodynamic therapy (PDT) for perianal bowenoid papulosis", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203408

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