Tumor responses after combined PDT and hyperthermia

Fred W. Hetzel; H. Chen; Qun Chen

doi:10.1117/12.203362

1 March 1995 Tumor responses after combined PDT and hyperthermia

Fred W. Hetzel, H. Chen, Qun Chen

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203362
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

The objective of this study is to investigate tumor responses when treated with the combination of photodynamic therapy and hyperthermia. Intra-tumoral oxygen levels (pO₂) and 30 day tumor regrowth were investigated. C3H murine mammary leg tumors were implanted and grown to a diameter of 6 mm. The combined treatment was designed based on the data from our previous studies of tumor response and tumor tissue oxygen levels after various doses of hyperthermia and PDT alone. Photofrin (12.5 mg/kg, i.p.) was administered to the animals 24 hours before light treatment (630 nm, 200 J/cm², 300 mW/cm²). Hyperthermia (43.5 degree(s)C, 30 to 90 minutes) was delivered 4 hours after the PDT treatment. TCD₆₀ and TCD₈₀ were observed for the combined therapy with 60 and 90 min hyperthermia, in comparison to the TCD₁₀ and TCD₂₀ for the hyperthermia alone, respectively. The results indicate that improved therapeutic results can be achieved with the combined therapy designed based on the tissue PO₂ profiles after single modality treatment.

Citation Download Citation

Fred W. Hetzel, H. Chen, and Qun Chen "Tumor responses after combined PDT and hyperthermia", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203362

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