Contrast and resolution in the optical-coherence microscopy of dense biological tissue

Michael J. Yadlowsky; Joseph M. Schmitt; Robert F. Bonner

doi:10.1117/12.206822

12 April 1995 Contrast and resolution in the optical-coherence microscopy of dense biological tissue

Michael J. Yadlowsky, Joseph M. Schmitt, Robert F. Bonner

Proceedings Volume 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II; (1995) https://doi.org/10.1117/12.206822
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

The mechanisms responsible for contrast in reflection mode imaging of turbid tissues at 1300 nm with an optical coherence microscope are addressed. A basic model is motivated and presented in which tissue backscatter is assumed to originate from substantially subwavelength scale refractive index fluctuations, while beam attenuation and decorrelation are attributed to structures larger than a wavelength. The sources of noise in OCM images are considered, particularly speckle, the behavior of which is calculated using the assumed properties of tissue. The speckle behavior is then used to estimate the contrast-detail performance of an OCM. The effects of multiple scattering on resolution and contrast are calculated numerically using a hybrid Monte Carlo/analytical model.

Citation Download Citation

Michael J. Yadlowsky, Joseph M. Schmitt, and Robert F. Bonner "Contrast and resolution in the optical-coherence microscopy of dense biological tissue", Proc. SPIE 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, (12 April 1995); https://doi.org/10.1117/12.206822

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