Volume-of-interest specification on arbitrarily resliced volume datasets

Gregory J. Klein; Bryan W. Reutter; Ronald H. Huesman; Pamela G. Coxson; Thomas F. Budinger

doi:10.1117/12.209694

24 May 1995 Volume-of-interest specification on arbitrarily resliced volume datasets

Gregory J. Klein, Bryan W. Reutter, Ronald H. Huesman, Pamela G. Coxson, Thomas F. Budinger

Proceedings Volume 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images; (1995) https://doi.org/10.1117/12.209694
Event: Medical Imaging 1995, 1995, San Diego, CA, United States

Abstract

In the physiologic modeling of dynamic positron emission tomography (PET) data, one is typically interested in the average reconstructed activity for voxels within the boundaries of some volume of interest (VOI), the uncertainty of this value, and possibly correlations with other VOIs. These calculations have been partially carried out in the past by drawing appropriate 2D regions on a number of reconstructed images in a PET volume, and then summing the voxel values within these regions. Summing voxel values in this fashion provides a value for activity within a volume, but does not allow calculation of the statistical uncertainty. To perform the latter task, calculations must be performed on the raw tomographic data, and thus the 2D regions must be specified on the originally acquired tomographic slices. We have developed software enabling clinicians to specify regions along any preferred viewing axis, and yet perform calculations on these regions to obtain the complete VOI covariance matrix. In this process, 2D regions are first drawn on slices of arbitrary orientation. Stacks of these regions are then tiled together to form a closed 3D surface model for each VOI. Cross sections of these VOIs in the originally acquired orientation are obtained by intersecting the 3D surface models with a series of appropriately transformed slicing planes. The resliced regions are then projected into tomographic sinogram space and the activity and uncertainty is calculated for each region. Knowledge of the complete covariance matrix allows combination of these 2D region activity values into 3D volume activity values and uncertainties.

Citation Download Citation

Gregory J. Klein, Bryan W. Reutter, Ronald H. Huesman, Pamela G. Coxson, and Thomas F. Budinger "Volume-of-interest specification on arbitrarily resliced volume datasets", Proc. SPIE 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images, (24 May 1995); https://doi.org/10.1117/12.209694

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available