Effective compensation for physical effects in 3D single-photon-emission-computed tomography

Xiaochuan Pan; Chunwu Wu; Chin-Tu Chen; Chien-Min Kao; John Nathan Aarsvold; Donald Gunter

doi:10.1117/12.216874

18 August 1995 Effective compensation for physical effects in 3D single-photon-emission-computed tomography

Xiaochuan Pan, Chunwu Wu, Chin-Tu Chen, Chien-Min Kao, John Nathan Aarsvold, Donald Gunter

Proceedings Volume 2622, Optical Engineering Midwest '95; (1995) https://doi.org/10.1117/12.216874
Event: Optical Engineering Midwest '95, 1995, Chicago, IL, United States

Abstract

SPECT can potentially be used for quantitative imaging of in vivo 3D radiopharmaceutical distributions. Attempts for accurate quantitation in 3D SPECT images have been compromise not only by the physical effects of photon attenuation, distance-dependent spatial resolution, and scattering, but also by the lack of effective and efficient methods that will correct for these effects. In this work, we introduce a one-step method that can effectively compensate for the effects of photon attenuation and distance-dependent spatial resolution in 3D SPECT. The correction for these effects requires only a very limited amount of computation in addition to that for 3D reconstruction and hence has the potential for routine clinical application. We use both computer-generated simulations and real data to validate the approach. The results demonstrate that the proposed one-step compensation method results in reconstructed 3D SPECT images with good quantitative information.

Citation Download Citation

Xiaochuan Pan, Chunwu Wu, Chin-Tu Chen, Chien-Min Kao, John Nathan Aarsvold, and Donald Gunter "Effective compensation for physical effects in 3D single-photon-emission-computed tomography", Proc. SPIE 2622, Optical Engineering Midwest '95, (18 August 1995); https://doi.org/10.1117/12.216874

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