Carrier systems in PDT II: accumulation strategies of biotin-avidin coupled photosensitizers developed on cultured tumor cells

Anja Ruebner-Heuermann; Joerg G. Moser; Alexander P. Savitzki; D. Berendij; Rainer Bayer; Birgit Wagner

doi:10.1117/12.230957

31 January 1996 Carrier systems in PDT II: accumulation strategies of biotin-avidin coupled photosensitizers developed on cultured tumor cells

Anja Ruebner-Heuermann, Joerg G. Moser, Alexander P. Savitzki, D. Berendij, Rainer Bayer, Birgit Wagner

Author Affiliations +

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230957
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Two possibilities to accumulate photosensitizing drugs at the surface of cultured tumor cells were exploited: biotinylation of the cell surface followed by avidin and dibiotin, and reaction with a biotinylated antibody followed by avidin and biotinylated sulfophthalocyanin. Both reactions were performed successfully. The latter leads to enhanced phototoxicity of the accumulated drug.

Citation Download Citation

Anja Ruebner-Heuermann, Joerg G. Moser, Alexander P. Savitzki, D. Berendij, Rainer Bayer, and Birgit Wagner "Carrier systems in PDT II: accumulation strategies of biotin-avidin coupled photosensitizers developed on cultured tumor cells", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230957

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available