Effect of desferrioxamine on production of ALA-induced Protoporphyrin IX in normal mouse skin

Qian Peng; Johan Moan; Vladimir Iani; Jahn M. Nesland

doi:10.1117/12.230941

31 January 1996 Effect of desferrioxamine on production of ALA-induced Protoporphyrin IX in normal mouse skin

Qian Peng, Johan Moan, Vladimir Iani, Jahn M. Nesland

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230941
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Topically applied ALA-PDT for human nodular basal cell carcinoma has encountered some problems, one of which is that the concentration of ALA-induced PpIX is in some cases too low to sensitize complete tumor destruction. Our present study, by means of an optical-fiber based point monitoring system in situ, has shown that the fluorescence intensity of PpIX was significantly higher in the normal skin of nude mice after topical application of ALA and desferrioxamine (DF) or in combination with DMSO than that of ALA alone or ALA plus DMSO. These data indicate that DF has an effect on enhancing the production of ALA- induced PpIX in the mouse skin. Thus, there may clinically be advantages of using ALA and DF over ALA alone in PDT of superficial skin lesions.

Citation Download Citation

Qian Peng, Johan Moan, Vladimir Iani, and Jahn M. Nesland "Effect of desferrioxamine on production of ALA-induced Protoporphyrin IX in normal mouse skin", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230941

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