In-vivo interleukin-1-alpha induction following chlorin-e6 photodynamic therapy in Balb/c mice

Piotr P. Ziolkowski; Krzysztof Symonowicz; Jerzy Milach

doi:10.1117/12.230989

31 January 1996 In-vivo interleukin-1-alpha induction following chlorin-e6 photodynamic therapy in Balb/c mice

Piotr P. Ziolkowski, Krzysztof Symonowicz, Jerzy Milach

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230989
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Photodynamic therapy may induce in in-vivo conditions the cytokine Interleukin-1-alpha in Balb/c mice. The sensitizer, i.e. chlorin e₆, in the doses 2.5 and 5.0 mg/kg of body weight followed by light treatment with doses 50 and 100 J/sq.cm resulted in the increase in serum levels of the cytokine. The levels of Interleukin-1-alpha have been determined at different time points using enzyme-linked immunosorbent assay (ELISA). These levels in control animals did not exceed the mean value of 15 pg/ml, whereas in photodynamically treated mice the levels were almost 3 - 4 times higher. The entire experiment has been carried out on healthy animals.

Citation Download Citation

Piotr P. Ziolkowski, Krzysztof Symonowicz, and Jerzy Milach "In-vivo interleukin-1-alpha induction following chlorin-e6 photodynamic therapy in Balb/c mice", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230989

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