Palliative treatment of patients with malignant structures of esophagus

Victor Ya. Zavodnov; M. I. Kuzin; Sergey S. Kharnas; Kirill G. Linkov; Victor B. Loschenov; Alexander A. Stratonnikov; Anna M. Posypanova

doi:10.1117/12.230999

31 January 1996 Palliative treatment of patients with malignant structures of esophagus

Victor Ya. Zavodnov, M. I. Kuzin, Sergey S. Kharnas, Kirill G. Linkov, Victor B. Loschenov, Alexander A. Stratonnikov, Anna M. Posypanova

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Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230999
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Photodynamic therapy with the use of laser endoscopic spectrum analyzer (LESA-5), spectral- analyzing video-imaging system, Kr laser and various types of catheters for different localizations and different geometry of tumor, and phthalocyanine aluminum photosensitizers in patients with malignant strictures of esophagus is discussed. Photodynamic therapy was carried out to four patients: with esophageal cancer (3 patients) and gastric cancer with infiltration of lower esophagus (1 patient). All patients suffered from severe dysphagia. Photosensitizer was used in a dose 1-1.5 mg/kg of weight. Usually we used 3-4 seances of laser treatment 10-30 minutes long. The accumulation of photosensitizer was controlled by LESA-5. Laser induced fluorescent image was monitored by the video-imaging system in order to control laser treatment. There were no side-effects. The results show high efficiency of photodynamic therapy. There was marked reduction of dysphagia symptoms in all cases. It seems that photodynamic therapy is a good alternative to palliative surgical treatment of patients with malignant strictures of esophagus.

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Victor Ya. Zavodnov, M. I. Kuzin, Sergey S. Kharnas, Kirill G. Linkov, Victor B. Loschenov, Alexander A. Stratonnikov, and Anna M. Posypanova "Palliative treatment of patients with malignant structures of esophagus", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230999

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KEYWORDS

Esophagus

Photodynamic therapy

Tumors

Laser therapeutics

Cancer

Aluminum

Endoscopes

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