Diagnosis of inflammatory rheumatic diseases with photon density waves

Juergen Beuthan; Viravuth Prapavat; Rolf-Dieter Naber; Olaf Minet; Gerhard J. Mueller

doi:10.1117/12.238824

24 April 1996 Diagnosis of inflammatory rheumatic diseases with photon density waves

Juergen Beuthan, Viravuth Prapavat, Rolf-Dieter Naber, Olaf Minet, Gerhard J. Mueller

Proceedings Volume 2676, Biomedical Sensing, Imaging, and Tracking Technologies I; (1996) https://doi.org/10.1117/12.238824
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Rheumatoid arthritis (RA) is a common inflammatory disease of interphalangeal joints. The utilization of conventional imaging systems (e.g. x-rays) for non invasive diagnostics at an early stage of the disease is difficult, since pathologically induced changes do not occur at this stage in hard tissue. Use of MR and ultrasound methods are both methodically problematic and expensive. Therefore investigations for optical diagnostics using photon density waves (PDW) were carried out. The PDW was realized with an intensity modulated laser diode (825 nm, f_mod: 110 MHz) and an ac- and phase detection in a 2D transillumination scanner. Measurements of optical properties of synovia and synovialis of healthy and early RA stages were performed and indicated a significant pathological increase of (mu) _s. The detected PDW-pictures provided corresponding results. Further investigations regarding the object- variation of the modulation transfer function provide a sufficient spatial resolution in order to assign functional changes to anatomical structures. The results are presented using photos.

Citation Download Citation

Juergen Beuthan, Viravuth Prapavat, Rolf-Dieter Naber, Olaf Minet, and Gerhard J. Mueller "Diagnosis of inflammatory rheumatic diseases with photon density waves", Proc. SPIE 2676, Biomedical Sensing, Imaging, and Tracking Technologies I, (24 April 1996); https://doi.org/10.1117/12.238824

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