Enhancement of the fluorescence cancer diagnostic method of tissues using diffuse reflectance and the analysis of oxygenation state

Niclolay N. Zhadin; Yuanlong Yang; Singaravelu Ganesan; Nathan Ockman; Robert R. Alfano

doi:10.1117/12.237582

5 April 1996 Enhancement of the fluorescence cancer diagnostic method of tissues using diffuse reflectance and the analysis of oxygenation state

Niclolay N. Zhadin, Yuanlong Yang, Singaravelu Ganesan, Nathan Ockman, Robert R. Alfano

Author Affiliations +

Proceedings Volume 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy; (1996) https://doi.org/10.1117/12.237582
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

We report on an analysis of diffuse reflectance spectra measured in conjunction with the fluorescence from normal human breast tissues and malignant breast tumors. The diffuse reflectance spectra from excised, air-equilibrated, human breast tissue samples show lower fractions of oxygenated hemoglobin and higher content of ferric (Fe³⁺) heme in malignant breast tumor samples than in normal breast tissues. Normal tissues are found to be easily deoxygenated and reoxygenated, but malignant tumors usually do not change their state as much. An analysis of tissue oxygenation parameters is discussed with respect to an enhancement of predictive power of fluorescence diagnostic method. The oxygenation state of tissues may be used as an additional marker in cancer diagnostics.

Citation Download Citation

Niclolay N. Zhadin, Yuanlong Yang, Singaravelu Ganesan, Nathan Ockman, and Robert R. Alfano "Enhancement of the fluorescence cancer diagnostic method of tissues using diffuse reflectance and the analysis of oxygenation state", Proc. SPIE 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy, (5 April 1996); https://doi.org/10.1117/12.237582

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