Photoeradication and imaging of atheromatous plaque with texaphyrins

Kathryn W. Woodburn; Fan Qing; David Kessel; Stuart W. Young M.D.

doi:10.1117/12.275065

22 May 1997 Photoeradication and imaging of atheromatous plaque with texaphyrins

Kathryn W. Woodburn, Fan Qing, David Kessel, Stuart W. Young M.D.

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275065
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Cardiovascular disease is the chief cause of death in the western world. Lutetium texaphyrin (PCI-0123) is a pure, synthetic, aqueous-soluble macrocycle that localizes in both cancerous lesions and atheromatous plaque. The lutetium texaphyrin complex is a potent photosensitizer in vivo, where it is activated by tissue-penetrating far red light (720 - 760 nm). Patient diagnosis and treatment planning are possible with PCI-0123 fluorescence imaging. In this study the localization and selective eradication of atheromatous plaque using PCI-0123 and photoangioplasty are discussed.

Citation Download Citation

Kathryn W. Woodburn, Fan Qing, David Kessel, and Stuart W. Young M.D. "Photoeradication and imaging of atheromatous plaque with texaphyrins", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275065

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