Photodynamic method used for the treatment of malignant melanoma and Merkel cell carcinoma

Janusz Domaniecki; Edward Stanowski M.D.; Alfreda Graczyk; M. Kalczak; Jerzy Struzyna; Miroslaw Kwasny; Zygmunt Mierczyk; M. Najdecki; J. Krupa

doi:10.1117/12.292837

23 October 1997 Photodynamic method used for the treatment of malignant melanoma and Merkel cell carcinoma

Janusz Domaniecki, Edward Stanowski M.D., Alfreda Graczyk, M. Kalczak, Jerzy Struzyna, Miroslaw Kwasny, Zygmunt Mierczyk, M. Najdecki, J. Krupa

Author Affiliations +

Proceedings Volume 3188, Laser Technology V: Applications in Medicine and Ecology; (1997) https://doi.org/10.1117/12.292837
Event: Laser Technology V, 1996, Szczecin, Poland

Abstract

A photodynamic method is successfully applied for tumor diagnosis treatment. We used such a method for a dozen or so patients with primary and metastatic skin tumors. As photosensitizers HpD (Arg)₂ and PP(Ala)₂(Arg)₂ were used in concentration of 1 mg/ml. The photosensitizers wee administered directly into tumors with a does of 0.1 divided by 0.2 ml. As a result of tumor irradiation by means of the He-Cd laser, a tumor intensively luminates what makes it possible to determine accurately its size and shape. Next, we applied a series of irradiation by means of He-Ne laser during the successive three days and patients received full dose of 150 J/cm² per tumor surface. For extensive tumors such an irradiation series was repeated after 7 days. The patients were divided into three groups depending on tumor size. The first group of patients with tumors of 0.5 cm of diameter showed very good treatment results just after the first series of irradiation. The second group of patients with tumors of 0.5-1.5 cm showed very good treatment results after two series of irradiation. The third group of patients with tumors of diameter over 1.0 cm showed acceptable treatment results after two series of irradiations, determined as sufficient ones. The patients from the third group wee operated on after 7 divided by 10 days from the time of the completed irradiation. The photodynamic method can be used as a method for tumor diagnosis and skin tumor treatment as well as a supplementary method for surgical intervention.

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Janusz Domaniecki, Edward Stanowski M.D., Alfreda Graczyk, M. Kalczak, Jerzy Struzyna, Miroslaw Kwasny, Zygmunt Mierczyk, M. Najdecki, and J. Krupa "Photodynamic method used for the treatment of malignant melanoma and Merkel cell carcinoma", Proc. SPIE 3188, Laser Technology V: Applications in Medicine and Ecology, (23 October 1997); https://doi.org/10.1117/12.292837

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