Processing, segmentation, and visualization of pre- and post-stent coronary arteries using intravascular ultrasound

David Richard Holmes III; Richard A. Robb

doi:10.1117/12.312550

26 June 1998 Processing, segmentation, and visualization of pre- and post-stent coronary arteries using intravascular ultrasound

David Richard Holmes III, Richard A. Robb

Author Affiliations +

Proceedings Volume 3335, Medical Imaging 1998: Image Display; (1998) https://doi.org/10.1117/12.312550
Event: Medical Imaging '98, 1998, San Diego, CA, United States

Abstract

Intra-vascular ultrasound (IVUS) has significant potential for providing new information about the structure and condition of the coronary arteries. However, these image datasets are inherently noisy and characterized by frequent drop-outs and shadowing, considerably constraining their use for quantitative evaluation of coronary artery integrity and stent augmentation. A feasibility study was conducted to test the effectiveness of a software toolkit for processing, segmenting, and visualizing pre- and post-stent IVUS datasets, as a precursor to detailed quantitative evaluation of IVUS with regard to characterization of coronary luminal wall properties. Frame averaging, histogram processing, and anisotropic diffusion were used to reduce speckle noise and compensate for image dropout and shadowing. A region of interest (ROI) analysis was conducted to determine the effectiveness of the image processing. Preliminary results suggest that the image processing steps are effective at increasing the contrast to speckle ratio. In addition, contrast between the arterial wall and lumen was improved, producing an edge enhancement effect. Image registration was used to align images within a volume (i.e. 2-D registration) and between volumes (i.e. 3-D registration). A voxel matching method was used for the 2-D registration and a surface matching method was used for 3-D registration. A morphological connect method for segmentation was used to extract large structures in the data. A new edge-based algorithm was developed to segment the data in regions where the other method failed. Volume rendering methods were used to visualize the data. These preliminary visualizations of processed, segmented and registered IVUS datasets illustrated encouraging potential for further quantitative analysis of coronary artery morphology and pathology.

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David Richard Holmes III and Richard A. Robb "Processing, segmentation, and visualization of pre- and post-stent coronary arteries using intravascular ultrasound", Proc. SPIE 3335, Medical Imaging 1998: Image Display, (26 June 1998); https://doi.org/10.1117/12.312550

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