Paper
22 May 1998 DNA sequence detection by means of two-bit correlation
Frederik Vanhaverbeke, Hugo Thienpont, Katarzyna Chalasinska-Macukow, Patrick Vanoostveldt
Author Affiliations +
Proceedings Volume 3490, Optics in Computing '98; (1998) https://doi.org/10.1117/12.308915
Event: Optics in Computing '98, 1998, Bruges, Belgium
Abstract
Since the arrival of new devices such as the spatial light modulators based on ferroelectric liquid crystals' , optical pattern recognition has known a revival. Almost all applications in optical pattern recognition are concerned with the recognition of objects in real images with industrial and military applications. For these applications there are major problems to make filters which are able to cope with rotations and scale-changes in the input-image2 along with the presence of noise in the image under investigation. Another recent application is in the field of securing information3. In this article we present a completely new application : we use optical pattern recognition for the recognition of a particular DNA-sequence in a very large DNA-string. We aim to code a genome sequence which is composed of DNAsequences, polymers build up by 4 different organic bases called : Adenine (A), Thymidine (T), Cytosine (C) and Guanine (G). The sequence of these bases in the polymer compose the coding of all biological information necessary to reproduce and grow as a living organism. The human genome is composed of 2.8 billion such bases, a typical virus like HIV contains about 9000 bases. The occurrence of these bases in the large DNA-strings is depending on the kind of DNA but in many cases this occurrence is almost random for the 4 bases. At this moment large efforts are done to resolve the complete sequence of the human genome and a lot of other living organisms. An important topic in genetics is the search for functional sequences in very large DNA-strings to acquire a better understanding of life and diseases. Nowadays, these searches are mainly performed by artificial intelligence techniques4 . In this article we show that optical pattern recognition can be a very effective and very fast alternative for these searches.
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Frederik Vanhaverbeke, Hugo Thienpont, Katarzyna Chalasinska-Macukow, and Patrick Vanoostveldt "DNA sequence detection by means of two-bit correlation", Proc. SPIE 3490, Optics in Computing '98, (22 May 1998); https://doi.org/10.1117/12.308915
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KEYWORDS
Phase modulation

Amplitude modulation

Image filtering

Optical pattern recognition

Modulation

Organisms

Phase only filters

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