Detection of carbon monoxide from biological tissue using difference frequency generation in periodically poled lithium niobate near 4.6 um

Yuji Morimoto; Jens Klattenhoff; William Durante; David G. Lancaster; Robert F. Curl; Frank K. Tittel

doi:10.1117/12.346754

21 April 1999 Detection of carbon monoxide from biological tissue using difference frequency generation in periodically poled lithium niobate near 4.6 μm

Yuji Morimoto, Jens Klattenhoff, William Durante, David G. Lancaster, Robert F. Curl, Frank K. Tittel

Author Affiliations +

Proceedings Volume 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II; (1999) https://doi.org/10.1117/12.346754
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

A mid-IR gas sensor using difference frequency generation was developed to measure trace levels of biological carbon monoxide (CO). A periodically-poled lithium niobate crystal is pumped by a continuous wave Ti:Sapphire laser and a compact diode pumped Nd:YAG laser operating at 864.86 and 1064.6 nm, respectively. The strong IR transition R(6) at 2169.2 cm^-1 is chosen for convenient CO detection without interference from other gas species. Carbon monoxide is collected and flowed into a multipass cell with an effective optical path length of 18.3 m. Using such an experimental arrangement, we detected the generation of CO at levels of 30 ppb during a 30 min period from living vascular smooth muscle cells in basal state.

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Yuji Morimoto, Jens Klattenhoff, William Durante, David G. Lancaster, Robert F. Curl, and Frank K. Tittel "Detection of carbon monoxide from biological tissue using difference frequency generation in periodically poled lithium niobate near 4.6 μm", Proc. SPIE 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II, (21 April 1999); https://doi.org/10.1117/12.346754

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