Sequential injection separation and sensing

Jay W. Grate; Oleg B. Egorov; Cynthia J. Bruckner-Lea

doi:10.1117/12.370272

18 November 1999 Sequential injection separation and sensing

Jay W. Grate, Oleg B. Egorov, Cynthia J. Bruckner-Lea

Proceedings Volume 3857, Chemical Microsensors and Applications II; (1999) https://doi.org/10.1117/12.370272
Event: Photonics East '99, 1999, Boston, MA, United States

Abstract

Automated microfluidic analysis has historically been carried out by flow injection analysis techniques. Sequential injection analysis represents a more versatile method for automated fluid handling. We have explored the use of sequential injection analysis for performing microcolumn separations. These separations can be used as part of a microanalytical procedure, or for sample preparation. In addition, with detection of retained species on the microcolumn, sequential injection separation represents a technique for sensing. Recently, it has been demonstrated that sequential injection separation can be carried out with renewable separation columns--the beads with interactive surfaces can be delivered to the microcolumn, used for processing the sample, and discarded after each measurement. Delivery of new beads for each measurement provides a method for renewable surface separation and renewable surface sensing. Applications in environmental analysis and bioanalytical chemistry will be presented.

Citation Download Citation

Jay W. Grate, Oleg B. Egorov, and Cynthia J. Bruckner-Lea "Sequential injection separation and sensing", Proc. SPIE 3857, Chemical Microsensors and Applications II, (18 November 1999); https://doi.org/10.1117/12.370272

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