In-vivo autofluorescence of nasopharyngeal carcinoma and normal tissue

Jianan Y. Qu; Po Wing Yuen; Zhijian Huang; William I. Wei

doi:10.1117/12.382732

19 April 2000 In-vivo autofluorescence of nasopharyngeal carcinoma and normal tissue

Jianan Y. Qu, Po Wing Yuen, Zhijian Huang, William I. Wei

Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382732
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

An optical imaging and spectroscopy system has been developed for the study of in vivo fluorescence of nasopharyngeal tissue through an endoscope. The system records the fluorescence signal in the imaging plane of the endoscopic system. This allows analyze the characteristics of the light induced fluorescence (LIF) spectra recorded by each pixel of the 2D detector which may be used for fluorescence endoscopic imaging. If the endoscope for fluorescence endoscopy is the same as one employed for the in vivo fluorescence study, the algorithms developed to distinguish the diseased tissue from normal tissue based on the in vivo fluorescence study should be highly reliable for fluorescence imaging of lesions. In this work, fluorescence spectra were collected from 27 full term patients. Different algorithms were tested for separation of cancerous lesions from normal tissue. High sensitivity and specificity were achieved.

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Jianan Y. Qu, Po Wing Yuen, Zhijian Huang, and William I. Wei "In-vivo autofluorescence of nasopharyngeal carcinoma and normal tissue", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382732

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KEYWORDS

Luminescence

Tissues

Endoscopy

In vivo imaging

Endoscopes

Imaging systems

Biopsy

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