Optical biopsy with long-range nondiffracting beams

Ervin Goldfain

doi:10.1117/12.382723

19 April 2000 Optical biopsy with long-range nondiffracting beams

Ervin Goldfain

Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382723
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Most current configurations for optical biopsy contain fiber optic bundles at both the delivery and receiving ends of the optical system. Some layouts include distal lenses to either collimate or focus the incident light at various depth locations across the tissue. The inherent beam divergence, along with the highly scattering nature of the living tissue, are known to limit the penetration depth of the probe and the spatial or temporal resolution of the detected signal. In this work we study a novel modality for tissue illumination based on the use of long-range nondiffracting beams (LRNB). LRNB represent narrow-width light pencils with a constant or linearly varying axial intensity that propagate over large distances without diffractive spreading. Recent tests have demonstrated that LRNB exhibit in significant intensity distortions when operated as beacon beams through atmospheric turbulence. Our numerical and software simulations show that LRNB may offer the potential for larger penetration depth and enhanced contrast over setups using conventional laser beams. Clinical applications include diagnosis, laser surgery and photodynamic therapy.

Citation Download Citation

Ervin Goldfain "Optical biopsy with long-range nondiffracting beams", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382723

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