Ultraviolet 2D fluorescence mapping system for the imaging of head and neck tumors

Alvin Katz; Howard E. Savage; Fanan Zeng; Jayson Rome; Stimson P. Schantz M.D.; Steven A. McCormick; Rubina S. Cocker; Robert R. Alfano

doi:10.1117/12.382727

19 April 2000 Ultraviolet 2D fluorescence mapping system for the imaging of head and neck tumors

Alvin Katz, Howard E. Savage, Fanan Zeng, Jayson Rome, Stimson P. Schantz M.D., Steven A. McCormick, Rubina S. Cocker, Robert R. Alfano

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Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382727
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Fluorescence images of ex vivo head and neck tissues were acquired at multiple combinations of emission and excitation wavelengths. The wavelength combinations were selected to map different tissue molecules and structures whose fluorescence signatures have bene used to detect cancer. Fluorescence maps were generated by ratioing fluorescence image intensities. These ratio maps enhanced the ability to recognize regions of tumor and other features in tissues. Histopathological analysis was performed on the tissue samples. Location and shape of features observed in the fluorescence images were correlated with structures observed in histopathology.

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Alvin Katz, Howard E. Savage, Fanan Zeng, Jayson Rome, Stimson P. Schantz M.D., Steven A. McCormick, Rubina S. Cocker, and Robert R. Alfano "Ultraviolet 2D fluorescence mapping system for the imaging of head and neck tumors", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382727

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