Reconstruction of 3D radial distribution of interphase chromatin in lymphocyte nucleus for various diseases

Igor Patrickeyev; Peter Frick; Alexander V. Zhukotsky

doi:10.1117/12.384205

27 April 2000 Reconstruction of 3D radial distribution of interphase chromatin in lymphocyte nucleus for various diseases

Igor Patrickeyev, Peter Frick, Alexander V. Zhukotsky

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Proceedings Volume 3921, Optical Diagnostics of Living Cells III; (2000) https://doi.org/10.1117/12.384205
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The wavelet tomography is used for statistical reconstruction of a lymphocyte nucleus for various diseases. The restored parameter is a probability density function (PDF) of radial distribution of condensed chromatin. In this content, PDF describes the cross-section of the nuclear structure of chromatin. Initial dat for reconstruction is the histogram of the chromatin granules, i.e. the number of granules versus the distance for the center of projection. This work is concerned with lymphocyte nuclei of peripheral blood for four groups of patients: control group; those who live in the area affected by the Chernobyl accident; mieloid group; leucose group. In contrast to the previous work, the new criteria of regularization is developed and used.

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Igor Patrickeyev, Peter Frick, and Alexander V. Zhukotsky "Reconstruction of 3D radial distribution of interphase chromatin in lymphocyte nucleus for various diseases", Proc. SPIE 3921, Optical Diagnostics of Living Cells III, (27 April 2000); https://doi.org/10.1117/12.384205

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KEYWORDS

Reconstruction algorithms

Wavelets

Tomography

Radon

Radon transform

Blood

Denoising

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