Optical study of magnetic sedimentation and orientable properties of blood cells

Svetlana B. Norina; Alexander N. Shalygin; Stanislav F. Rastopov

doi:10.1117/12.387136

31 May 2000 Optical study of magnetic sedimentation and orientable properties of blood cells

Svetlana B. Norina, Alexander N. Shalygin, Stanislav F. Rastopov

Proceedings Volume 3923, Optical Diagnostics of Biological Fluids V; (2000) https://doi.org/10.1117/12.387136
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Magnetic sedimentation processes near ferromagnetic wire were applied for the cellular and the biotechnological monitoring. Numerous biological applications of magnetic sedimentation, or high gradient magnetic separation (HGMS), achieved mainly for human blood cells, have shown that it is possible to distinguish between the diamagnetic Fe-zero-spin oxidized states and the paramagnetic Fe-high-spin reduced ones in red blood cells. The precision methods of the measurements of capture travelling (magnetic diffusion) time or accumulation (magnetic sedimentation) radius in HGMS have shown that it is really to determine the weak dia- or paramagnetic shifts of magnetic susceptibility up to 0.7 (DOT) 10^-10 (SI). The capture and sedimentation of particles with 5 - 40 micrometers sizes on single magnetized wires were investigated using microscopic video-recording type. Magnetic susceptibility bars for cells in normal and disturbed states demonstrated the high reproducibility and narrow distribution patterns.

Citation Download Citation

Svetlana B. Norina, Alexander N. Shalygin, and Stanislav F. Rastopov "Optical study of magnetic sedimentation and orientable properties of blood cells", Proc. SPIE 3923, Optical Diagnostics of Biological Fluids V, (31 May 2000); https://doi.org/10.1117/12.387136

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