Quantitative characterization of the progression of focal brain ischemia in a rat photochemical stroke model using in-vivo MRI

Anne-Marie Van der Linden; Marleen Verhoye; M. De Ryck

doi:10.1117/12.383430

20 April 2000 Quantitative characterization of the progression of focal brain ischemia in a rat photochemical stroke model using in-vivo MRI

Anne-Marie Van der Linden, Marleen Verhoye, M. De Ryck

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Proceedings Volume 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images; (2000) https://doi.org/10.1117/12.383430
Event: Medical Imaging 2000, 2000, San Diego, CA, United States

Abstract

Stroke models, if used in drug evaluation studies, should have a predictable and reproducible course and outcome. While most drug trials focus on the lesion outcome, our study shows the importance of studying lesion growth instead of lesion outcome. In the study reported here, the time course of a photochemically induced neocortical infarct is studied in rats, using diffusion-weighted magnetic resonance imaging, while the rats were submitted to a rigorous control of physiological parameters, ensuring constant body temperature, blood gases (pO₂ and pCO₂), arterial pressure, heart rate and plasma glucose levels. Under such a stable physiological condition, rats were imaged as soon as possible after lesion up to 6 hours, which is the most important period to determine the slope of further lesion growth and final outcome. The data show that the initial size of the lesion is important for the further outcome of the stroke, both in lesion size and severity of the ischemic damage, as reflected by changes in the Apparent Diffusion Coefficient.

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Anne-Marie Van der Linden, Marleen Verhoye, and M. De Ryck "Quantitative characterization of the progression of focal brain ischemia in a rat photochemical stroke model using in-vivo MRI", Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); https://doi.org/10.1117/12.383430

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KEYWORDS

Magnetic resonance imaging

Blood

Brain

Gases

Glucose

Heart

Ischemia

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