Near-infrared optical imager for cerebral blood flow and oxygenation detection

Ichiro Oda; Yukihisa Wada; Sadao Takeuchi; Yukio Oikawa; Naojumi Sakauchi; Yasunobu Ito; Ikuo Konishi; Yoshio Tsunazawa; Takashi Kusaka; Kenichi Isobe; Susumu Itoh; Shoju Onishi

doi:10.1117/12.434516

29 June 2001 Near-infrared optical imager for cerebral blood flow and oxygenation detection

Ichiro Oda, Yukihisa Wada, Sadao Takeuchi, Yukio Oikawa, Naojumi Sakauchi, Yasunobu Ito, Ikuo Konishi, Yoshio Tsunazawa, Takashi Kusaka, Kenichi Isobe, Susumu Itoh, Shoju Onishi

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434516
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

This paper describes the theory and the apparatus on our newly developed 64 channel optical imager that enables imaging of three components, indocyanine green (ICG), oxyHb and deoxyHb. Knowledge on blood flow is obtainable using ICG as a blood flow indicator that is to be introduced via injection. ICG has a strong absorption at 805nm, therefore the changes in ICG is detectable with NIR spectroscopy separating from oxyHb and deoxyHb using proper three wavelengths. In addition to the system description, it describes an animal experiment and a phantom test for the validation study. It discusses independence features of ICG on Hb values. Using a simple quasi Lambert Beer's law, it proved the excellent separation of the three components. It also discusses the factors that affect the performance of signal separation.

Citation Download Citation

Ichiro Oda, Yukihisa Wada, Sadao Takeuchi, Yukio Oikawa, Naojumi Sakauchi, Yasunobu Ito, Ikuo Konishi, Yoshio Tsunazawa, Takashi Kusaka, Kenichi Isobe, Susumu Itoh, and Shoju Onishi "Near-infrared optical imager for cerebral blood flow and oxygenation detection", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434516

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