In-vivo optical biopsy of the human retina using optical coherence tomography

Wolfgang Drexler; Ravi K. Ghanta; Joel S. Schuman; Tony H. Ko; Uwe Morgner; Franz X. Kaertner; James G. Fujimoto

doi:10.1117/12.427892

23 May 2001 In-vivo optical biopsy of the human retina using optical coherence tomography

Wolfgang Drexler, Ravi K. Ghanta, Joel S. Schuman, Tony H. Ko, Uwe Morgner, Franz X. Kaertner, James G. Fujimoto

Proceedings Volume 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V; (2001) https://doi.org/10.1117/12.427892
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Using state of the art laser technology, third generation ophthalmologic optical coherence tomography (OCT) has been developed which enables ultrahigh resolution, non-invasive in vivo imaging of retinal morphology with an unprecedented axial resolution of 3 micrometers . This represents a quantum leap in performance over the 10-15 micrometers resolution currently available in ophthalmic OCT systems and, to our knowledge, is the highest resolution in vivo ophthalmologic imaging achieved to date. This resolution enables optical biopsy, i.e. the in vivo visualization of intraretinal architectural morphology which had previously only been possible with histopathology. Image processing and segmentation techniques are demonstrated for automatic identification and quantification of retinal morphology. Ultrahigh resolution ophthalmic OCT has the potential to enhance the sensitivity and specificity for early diagnosis of several ocular diseases, e.g. glaucoma, which requires precise imaging and measurement of retinal nerve fiber layer thickness, as well as improve monitoring of disease progression and efficacy of therapy.

Citation Download Citation

Wolfgang Drexler, Ravi K. Ghanta, Joel S. Schuman, Tony H. Ko, Uwe Morgner, Franz X. Kaertner, and James G. Fujimoto "In-vivo optical biopsy of the human retina using optical coherence tomography", Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, (23 May 2001); https://doi.org/10.1117/12.427892

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