Random signal model for cDNA microarrays

Yoganand Balagurunathan; Edward R. Dougherty; Yidong Chen; Michael L. Bittner; Jeffrey M. Trent

doi:10.1117/12.427985

4 June 2001 Random signal model for cDNA microarrays

Yoganand Balagurunathan, Edward R. Dougherty, Yidong Chen, Michael L. Bittner, Jeffrey M. Trent

Proceedings Volume 4266, Microarrays: Optical Technologies and Informatics; (2001) https://doi.org/10.1117/12.427985
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The images resulting from cDNA microarrays are highly random. There are many aspects to this randomness, including spot size, shape, intensity, uniformity, and circularity, as well as both foreground and background noise. This paper presents a random model for the generation of microarray images. The model is complicated and contains over 20 parameters. It can be used to test microarray imaging algorithms and to simulate the effects of various dependencies within the image formation process.

Citation Download Citation

Yoganand Balagurunathan, Edward R. Dougherty, Yidong Chen, Michael L. Bittner, and Jeffrey M. Trent "Random signal model for cDNA microarrays", Proc. SPIE 4266, Microarrays: Optical Technologies and Informatics, (4 June 2001); https://doi.org/10.1117/12.427985

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